Coronavirus

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Joe Shlabotnik
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Re: Coronavirus

Post by Joe Shlabotnik »

IMADreamer wrote: ↑
October 26 20, 3:52 pm
Joe Shlabotnik wrote: ↑
October 26 20, 1:32 pm
IMADreamer wrote: ↑
October 26 20, 1:00 pm
Well this got ugly fast. My wife calls me crying at lunch today, she has been working with someone who is covid positive for almost a week now. Because the person isn't showing signs, her Trumper, covid denier boss told the lady she needed to be at work. My wife just found out today. I told her to come home. Meanwhile, I found out who her bosses boss is and I called them and completely unloaded. I'm pretty sure I made that lady cry. She said she would take immediate action and I said we are too, as we have a lawyer. Well my wife gets a message a little bit ago that her boss, her bosses boss, and like four other people have been fired. [expletive] good.

If my wife gets sick, we are suing the living [expletive] out of them.
Good for you. Who does she work for - small business or corporation?

She works for a huge company pretending to be a small business. They try and keep it hush hush but they are owned by a huge health care provider.
A health care provider was forcing someone with Covid to be at work? Jesus. :obucardheadbang:

I work for a huge mutli-national Cummins. They've been taking it real seriously. In fact we just got word that a member of the janitor staff tested positive last week. They wanted anyone in the building at the same time this person was to get tested. They've told us over and over, if we feel sick and think we've been exposed, stay home and get tested.

Jocephus
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Re: Coronavirus

Post by Jocephus »

mini poll: do you think the US will cross 100,000 cases in a day before end of year?

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mikechamp
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Re: Coronavirus

Post by mikechamp »

This does not bode well, and I wonder what this means for a vaccine:
Antibodies 'fall rapidly after infection'

Levels of protective antibodies in people wane "quite rapidly" after coronavirus infection, say researchers. Antibodies are a key part of our immune defences and stop the virus from getting inside the body's cells.

The Imperial College London team found the number of people testing positive for antibodies has fallen by 26% between June and September. They say immunity appears to be fading and there is a risk of catching the virus multiple times.

The news comes as figures from the Office for National Statistics show that the number of Covid-19 deaths in the UK rose by 60% in the week of 16 October. The ONS figures suggest there have now been more than 60,000 deaths involving Covid-19 in the UK.

More than 350,000 people in England have taken an antibody test as part of the REACT-2 study so far. In the first round of testing, at the end of June and the beginning of July, about 60 in 1,000 people had detectable antibodies. But in the latest set of tests, in September, only 44 per 1,000 people were positive.

https://www.bbc.com/news/health-54696873

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obucard
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Re: Coronavirus

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Probably that it would become a regular occurrence, like the flu shot. They might even combine them, like they do with DPT and MMR.

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Re: Coronavirus

Post by AWvsCBsteeeerike3 »

I'm going to summarize, likely poorly, my understanding of the presence of antibodies, what that means for the immune response, and why the decreasing number of those with antibodies may not necessarily be alarming.

First, here's a graph, no idea or not if it will show up but you can click the link to see the graph.

Image

Basically, the main takeaway is the IgG antibodies were known some time ago to fade after the infection was beaten down by the body. It may now be better known that those IgG antibodies last only 6 months or 3 months, but likely not a year. So, that's better known...which is okay.

Antibodies more/less attach to a virus and prevent it from getting into the cell where the virus replicates. I don't know if there is a good analogy here. But, let's go with ...

[analogy] a virus (sars-cov-2 in this case) is a home intruder. An antibody (IgG) is a guard dog. Ideally, the intruder tries to come into your house, but the dog sees him, latches onto his arm in the front yard, and the intruder doesn't come inside the house.

But, at first because you live in a nice area and intruders are a novel thing in your neighborhood, your dog is simply Hercules and not yet The Beast. He isn't a trained assassin and is used to idly sleeping and drooling on baseballs that wonder into the backyard every now and then. He isn't trained to detect intruders and he isn't living outside. However, fool me once shame on you, fool me twice shame on me; and you get broken into. At which point, over the next couple weeks you train the dog to become aggressive towards inruders and put him outside. You have to teach him to be The Beast. OVer the next couple weeks, that dog is a killing machine and at watch 24/7. As a matter of fact, you create a couple thousand clones of The Beast to put in the front yard. But, with time and no intruders around, the dogs become lazy. Some of them run away. Your yard starts to smell and complaints are filed with the City. The City comes by and says, yo, you can't have this many dogs so you find them nice homes down the street. But, of course, you're going to keep Hercules plus a couple and even if they return to their previous life as inside dogs and don't stand at watch 24/7, they haven't forgotten about the threat of an intruder. If one so happens to come around and tries to steal a Babe Ruth signed baseball, even if the dogs are back to being Hercules, they are ready to turn back into The Beast in a heartbeat.[/analogy]

I don't know if that analogy is perfect yet (though antibodies certainly don't have to be actively detectable to be ready to ramp up production), nor does the imperial college that released the study. They just note that the amount of guard dogs in the front yard decreased. The body still has memory cells and its entirely possible those memory cells, while dormant, aren't making IgG but stand at the ready with the first detection of Sars-Cov-2 to kick back into gear to ramp up IgG production instantaneously as opposed to the week or two it originally took during the first infection. IF that's the case, while immunity may not be 100%, it's a pretty good bet even without detectable levels of IgG, any long term effects and/or fatalities will be greatly diminished the second/third/fourth/etc infection.

And, that would be rosy. Of course, we also can't be certain yet that the virus won't mutate to the point where even if IgG is made, it will be effective. Or, worse, the virus could mutate to use IgG against the host making it more dangerous.... which would be akin to The Beast returning and eating James Earl Jones.

All that said, it's not as cut and dried as it is made out to be. One thing is certain, and that is mutations of SC2 are happening far less quickly than they do with the flu. So, the real question is rather or not the memory cells will react to produce IgG or other antibodies capable of fighting of SC2, how effective will they be if so, and how long will that memory last if proven to be effective?

AWvsCBsteeeerike3
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Re: Coronavirus

Post by AWvsCBsteeeerike3 »

Also, to add to all that....and this goes back to the discussion of the innate v adaptive arms of the immune system, its worth reiterating that the innate arm can fight off infections quite well in some amount of people. The adaptive arm is responsible for making antibodies so it's possible to be infected and fight it off with no antibody production. Further, it is possible that once the body has memory cells that recognize the virus, the innate arm will be strengthened to some degree which will aid the body fight off the infection without the presence of antibodies.

Going back to the analogy, it would be like you installed a home security system instead of getting a bunch of dogs.

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pioneer98
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Re: Coronavirus

Post by pioneer98 »

Jocephus wrote: ↑
October 28 20, 2:05 pm
mini poll: do you think the US will cross 100,000 cases in a day before end of year?
I'm going to say yes but not by much.

Today had the highest number of new infections on record (81,581), just barely surpassing the one set 5 days ago (81,424).

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ghostrunner
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Re: Coronavirus

Post by ghostrunner »

This is a great visualization of how Covid can spread through a room or other indoor space. Different scenarios are presented with/without masks and ventilation.

https://english.elpais.com/society/2020 ... e-air.html

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ghostrunner
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Re: Coronavirus

Post by ghostrunner »

Son was exposed at school so him and 10 other students got sent home. Has to quarantine until next week because exposure was apparently last Tuesday. They assign seat numbers everywhere so they have a good idea who was near who and for how long. Already had him test and result was negative and he’s had no symptoms. He took a 48 hour test too so we’ll see how that comes back. Seems like all is good but it sucks for him. This would have been his third week back.

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Re: Coronavirus

Post by Jocephus »

not to ruffle any feathers but i was reminded that the sturgis rally was in middle of august...too bad we'll never really know how impactful those decisions were

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